Drug interactions
Hydroxyzine + Lofepramine
Severity: Moderate
Hydroxyzine and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and have anticholinergic activity, so together they can increase drowsiness and anticholinergic effects like dry mouth, constipation and urinary retention. Hydroxyzine may also contribute to QT prolongation alongside tricyclics.
What this interaction means in plain words
Hydroxyzine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, antimuscarinic effects and possible additive QT prolongation.
What to do
Monitor for oversedation and anticholinergic effects, with lower doses in older patients. Consider an ECG if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Lofepramine?
MediHelp rates the interaction as moderate. Hydroxyzine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and have anticholinergic activity, so together they can increase drowsiness and anticholinergic effects like dry mouth, constipation and urinary retention. Hydroxyzine may also contribute to QT prolongation alongside tricyclics.
How serious is the interaction between Hydroxyzine and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, with lower doses in older patients. Consider an ECG if other QT risk factors are present.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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