Drug interactions
Hydroxyzine + Loxapine inhaled
Severity: Moderate
Hydroxyzine and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine causes sedation and can cause bronchospasm, and hydroxyzine adds sedative and anticholinergic effects. The combination may increase drowsiness and impair alertness.
What this interaction means in plain words
Hydroxyzine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; loxapine is a dopamine and serotonin antagonist with antihistaminic activity.
What to do
Monitor for excessive sedation and observe the patient after loxapine administration. Reduce the hydroxyzine dose if drowsiness is prominent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Loxapine inhaled?
MediHelp rates the interaction as moderate. Hydroxyzine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine causes sedation and can cause bronchospasm, and hydroxyzine adds sedative and anticholinergic effects. The combination may increase drowsiness and impair alertness.
How serious is the interaction between Hydroxyzine and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and observe the patient after loxapine administration. Reduce the hydroxyzine dose if drowsiness is prominent.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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