Drug interactions
Hydroxyzine + Marijuana
Severity: Moderate
Hydroxyzine and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can cause drowsiness and impaired cognition and coordination, and hydroxyzine may add to these effects. Anticholinergic effects and tachycardia may also be more pronounced.
What this interaction means in plain words
Hydroxyzine and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via cannabinoid receptor activity and H1 antagonism.
What to do
Counsel patients to avoid driving or hazardous tasks and to limit cannabis use during hydroxyzine therapy. Monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Marijuana?
MediHelp rates the interaction as moderate. Hydroxyzine and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis can cause drowsiness and impaired cognition and coordination, and hydroxyzine may add to these effects. Anticholinergic effects and tachycardia may also be more pronounced.
How serious is the interaction between Hydroxyzine and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving or hazardous tasks and to limit cannabis use during hydroxyzine therapy. Monitor for oversedation.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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