Drug interactions
Hydroxyzine + Methylenedioxymethamphetamine
Severity: Moderate
Hydroxyzine and Methylenedioxymethamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is an illicit stimulant with serotonergic and sympathomimetic effects, while hydroxyzine is sedating and can prolong the QT interval. Both can affect cardiac conduction and the sedation effects may mask intoxication, so the combination is unpredictable.
What this interaction means in plain words
Hydroxyzine and Methylenedioxymethamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS effects plus possible additive QT and cardiovascular effects; the interaction is not well characterized.
What to do
Advise against recreational MDMA use during hydroxyzine therapy; in intoxicated patients monitor ECG, temperature and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Methylenedioxymethamphetamine?
MediHelp rates the interaction as moderate. Hydroxyzine and Methylenedioxymethamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MDMA is an illicit stimulant with serotonergic and sympathomimetic effects, while hydroxyzine is sedating and can prolong the QT interval. Both can affect cardiac conduction and the sedation effects may mask intoxication, so the combination is unpredictable.
How serious is the interaction between Hydroxyzine and Methylenedioxymethamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against recreational MDMA use during hydroxyzine therapy; in intoxicated patients monitor ECG, temperature and blood pressure.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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