Drug interactions
Hydroxyzine + Metoclopramide intranasal
Severity: Moderate
Hydroxyzine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents act on the central nervous system and may add to sedation and drowsiness. Metoclopramide can also cause extrapyramidal reactions, and the sedative effect of hydroxyzine may compound impaired alertness.
What this interaction means in plain words
Hydroxyzine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects; metoclopramide's central dopamine antagonism adds to hydroxyzine's sedation.
What to do
Counsel the patient about additive drowsiness and avoid driving or hazardous tasks. Monitor for extrapyramidal symptoms and reduce or stop one agent if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Hydroxyzine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents act on the central nervous system and may add to sedation and drowsiness. Metoclopramide can also cause extrapyramidal reactions, and the sedative effect of hydroxyzine may compound impaired alertness.
How serious is the interaction between Hydroxyzine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about additive drowsiness and avoid driving or hazardous tasks. Monitor for extrapyramidal symptoms and reduce or stop one agent if sedation is excessive.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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