Drug interactions
Hydroxyzine + Moxonidine
Severity: Moderate
Hydroxyzine and Moxonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and moxonidine may lower blood pressure. Combined use may increase sedation, dizziness and impaired alertness.
What this interaction means in plain words
Hydroxyzine and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from H1 antagonism and central imidazoline/alpha-2 agonism.
What to do
Start with the lower hydroxyzine dose and monitor for sedation and hypotension; counsel about driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Moxonidine?
MediHelp rates the interaction as moderate. Hydroxyzine and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and moxonidine may lower blood pressure. Combined use may increase sedation, dizziness and impaired alertness.
How serious is the interaction between Hydroxyzine and Moxonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lower hydroxyzine dose and monitor for sedation and hypotension; counsel about driving and machinery.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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