Drug interactions
Hydroxyzine + Norepinephrine
Severity: Minor
Hydroxyzine and Norepinephrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norepinephrine is an intravenous vasopressor used in critical care, and hydroxyzine is a sedating antihistamine. No meaningful sedation interaction is established, and hydroxyzine's mild alpha-blocking activity could slightly blunt pressor response.
What this interaction means in plain words
Hydroxyzine and Norepinephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects; hydroxyzine has weak alpha-1 antagonism while norepinephrine is an alpha agonist.
What to do
No dose change is usually needed; titrate norepinephrine to blood pressure target.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Norepinephrine?
MediHelp rates the interaction as minor. Hydroxyzine and Norepinephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Norepinephrine is an intravenous vasopressor used in critical care, and hydroxyzine is a sedating antihistamine. No meaningful sedation interaction is established, and hydroxyzine's mild alpha-blocking activity could slightly blunt pressor response.
How serious is the interaction between Hydroxyzine and Norepinephrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; titrate norepinephrine to blood pressure target.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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