Drug interactions
Hydroxyzine + Octreotide
Severity: Moderate
Hydroxyzine and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine has a recognized risk of QT prolongation and torsades de pointes, and octreotide may add to this through QT effects and bradycardia. The risk is greater with other risk factors such as cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Hydroxyzine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Octreotide belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Use the lowest effective hydroxyzine dose and monitor ECG and electrolytes in patients with cardiac risk factors. Consider a non-QT-prolonging alternative if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Octreotide?
MediHelp rates the interaction as moderate. Hydroxyzine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine has a recognized risk of QT prolongation and torsades de pointes, and octreotide may add to this through QT effects and bradycardia. The risk is greater with other risk factors such as cardiac disease or electrolyte disturbances.
How serious is the interaction between Hydroxyzine and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective hydroxyzine dose and monitor ECG and electrolytes in patients with cardiac risk factors. Consider a non-QT-prolonging alternative if feasible.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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