Drug interactions
Hydroxyzine + Olopatadine intranasal
Severity: Moderate
Hydroxyzine and Olopatadine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal olopatadine can cause somnolence, and hydroxyzine is strongly sedating, so together they may cause additive drowsiness and impaired psychomotor performance. This may affect driving and daily activities.
What this interaction means in plain words
Hydroxyzine and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from central H1 receptor antagonism.
What to do
Avoid duplicate antihistamine therapy where possible and advise against driving or operating machinery. Consider lowering the hydroxyzine dose or using a non-sedating alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Olopatadine intranasal?
MediHelp rates the interaction as moderate. Hydroxyzine and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal olopatadine can cause somnolence, and hydroxyzine is strongly sedating, so together they may cause additive drowsiness and impaired psychomotor performance. This may affect driving and daily activities.
How serious is the interaction between Hydroxyzine and Olopatadine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate antihistamine therapy where possible and advise against driving or operating machinery. Consider lowering the hydroxyzine dose or using a non-sedating alternative.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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