Drug interactions
Hydroxyzine + Papaveretum
Severity: Major
Hydroxyzine and Papaveretum: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids such as morphine, and with hydroxyzine may give additive sedation and respiratory depression. Hydroxyzine is sometimes used with opioids deliberately but dosing needs care.
What this interaction means in plain words
Hydroxyzine and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid agonism and H1 antagonism.
What to do
Use reduced doses of each and monitor respiratory rate and level of sedation, especially in elderly or opioid-naive patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Papaveretum?
MediHelp rates the interaction as major. Hydroxyzine and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum contains opium alkaloids such as morphine, and with hydroxyzine may give additive sedation and respiratory depression. Hydroxyzine is sometimes used with opioids deliberately but dosing needs care.
How serious is the interaction between Hydroxyzine and Papaveretum?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced doses of each and monitor respiratory rate and level of sedation, especially in elderly or opioid-naive patients.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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