Drug interactions
Hydroxyzine + Passion flower
Severity: Minor
Hydroxyzine and Passion flower: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Passion flower has mild sedative properties and may add to the drowsiness caused by hydroxyzine. Impaired concentration and psychomotor performance are possible.
What this interaction means in plain words
Hydroxyzine and Passion flower have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depression, probably via GABAergic activity of the herb; evidence is theoretical.
What to do
Counsel on drowsiness and avoid driving until response is known; discontinue the herb if sedation is excessive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Passion flower?
MediHelp rates the interaction as minor. Hydroxyzine and Passion flower have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Passion flower has mild sedative properties and may add to the drowsiness caused by hydroxyzine. Impaired concentration and psychomotor performance are possible.
How serious is the interaction between Hydroxyzine and Passion flower?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and avoid driving until response is known; discontinue the herb if sedation is excessive.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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