Drug interactions
Hydroxyzine + Sage
Severity: Minor
Hydroxyzine and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some sage species have reported sedative effects, so concurrent use with hydroxyzine may modestly increase drowsiness. Evidence is largely theoretical.
What this interaction means in plain words
Hydroxyzine and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; the mechanism is not well characterized.
What to do
Counsel patients on possible added drowsiness and avoid driving if affected. Stop the supplement if sedation becomes problematic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Sage?
MediHelp rates the interaction as minor. Hydroxyzine and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some sage species have reported sedative effects, so concurrent use with hydroxyzine may modestly increase drowsiness. Evidence is largely theoretical.
How serious is the interaction between Hydroxyzine and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on possible added drowsiness and avoid driving if affected. Stop the supplement if sedation becomes problematic.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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