Drug interactions
Hydroxyzine + Scullcap
Severity: Moderate
Hydroxyzine and Scullcap: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap has reputed sedative properties and may add to the drowsiness caused by hydroxyzine. Impaired alertness and psychomotor performance may result.
What this interaction means in plain words
Hydroxyzine and Scullcap can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects; the herb's sedative activity is poorly characterized.
What to do
Advise patients to avoid driving or hazardous tasks until response is known. Consider stopping the herbal product if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Scullcap?
MediHelp rates the interaction as moderate. Hydroxyzine and Scullcap can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Skullcap has reputed sedative properties and may add to the drowsiness caused by hydroxyzine. Impaired alertness and psychomotor performance may result.
How serious is the interaction between Hydroxyzine and Scullcap?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving or hazardous tasks until response is known. Consider stopping the herbal product if excessive sedation occurs.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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