Drug interactions
Hydroxyzine + Thiothixene
Severity: Moderate
Hydroxyzine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, and they may also affect cardiac repolarization and add anticholinergic effects. Combined use can cause excessive drowsiness and hypotension.
What this interaction means in plain words
Hydroxyzine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antihistaminic or anticholinergic effects.
What to do
Monitor sedation and blood pressure, and consider an ECG if other QT-prolonging risks exist. Adjust doses downward if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Thiothixene?
MediHelp rates the interaction as moderate. Hydroxyzine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, and they may also affect cardiac repolarization and add anticholinergic effects. Combined use can cause excessive drowsiness and hypotension.
How serious is the interaction between Hydroxyzine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, and consider an ECG if other QT-prolonging risks exist. Adjust doses downward if sedation is excessive.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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