Drug interactions
Hydroxyzine + Topiramate
Severity: Minor
Hydroxyzine and Topiramate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is sedating, and with topiramate it can increase drowsiness and slow thinking. This may affect driving and daily activities.
What this interaction means in plain words
Hydroxyzine and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydroxyzine belongs to Respiratory; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of topiramate and hydroxyzine.
What to do
Warn the patient about additive sedation and avoid driving until the response is known. Use the lowest effective hydroxyzine dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Topiramate
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Topiramate?
MediHelp rates the interaction as minor. Hydroxyzine and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxyzine is sedating, and with topiramate it can increase drowsiness and slow thinking. This may affect driving and daily activities.
How serious is the interaction between Hydroxyzine and Topiramate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about additive sedation and avoid driving until the response is known. Use the lowest effective hydroxyzine dose.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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