Drug interactions
Hydroxyzine + Triprolidine
Severity: Moderate
Hydroxyzine and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating H1 antihistamines with anticholinergic activity, so taking them together duplicates therapy. This leads to more drowsiness, impaired psychomotor performance and anticholinergic effects such as dry mouth, urinary retention and confusion, especially in older adults.
What this interaction means in plain words
Hydroxyzine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Triprolidine belongs to Respiratory.
Why it happens
Additive H1-receptor blockade with additive CNS depression and anticholinergic effects.
What to do
Avoid using two sedating antihistamines together and choose one agent or a non-sedating alternative. If both are unavoidable, monitor for sedation and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Triprolidine?
MediHelp rates the interaction as moderate. Hydroxyzine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating H1 antihistamines with anticholinergic activity, so taking them together duplicates therapy. This leads to more drowsiness, impaired psychomotor performance and anticholinergic effects such as dry mouth, urinary retention and confusion, especially in older adults.
How serious is the interaction between Hydroxyzine and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two sedating antihistamines together and choose one agent or a non-sedating alternative. If both are unavoidable, monitor for sedation and anticholinergic effects.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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