Drug interactions
Hydroxyzine + Zotepine
Severity: Moderate
Hydroxyzine and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, and zotepine also affects cardiac conduction and lowers seizure threshold. Combined use can cause marked drowsiness and hypotension, with possible additive QT effects.
What this interaction means in plain words
Hydroxyzine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antihistaminic effects, with possible additive QT prolongation.
What to do
Monitor sedation and blood pressure, and consider ECG monitoring if QT risk factors exist. Lower doses if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Zotepine?
MediHelp rates the interaction as moderate. Hydroxyzine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, and zotepine also affects cardiac conduction and lowers seizure threshold. Combined use can cause marked drowsiness and hypotension, with possible additive QT effects.
How serious is the interaction between Hydroxyzine and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, and consider ECG monitoring if QT risk factors exist. Lower doses if oversedation occurs.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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