Drug interactions
Ibrutinib + Ketoprofen
Severity: Moderate
Ibrutinib and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and carries a bleeding risk, which is increased by NSAIDs that also inhibit platelets and irritate the gastric mucosa. This raises the chance of significant gastrointestinal or other hemorrhage.
What this interaction means in plain words
Ibrutinib and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibrutinib belongs to Oncology; Ketoprofen belongs to Musculoskeletal.
Why it happens
Additive impairment of platelet function through BTK inhibition and cyclooxygenase inhibition.
What to do
Avoid regular NSAID use where possible, choose paracetamol for analgesia, and monitor for bleeding signs if combined. Consider gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Ketoprofen?
MediHelp rates the interaction as moderate. Ibrutinib and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs platelet function and carries a bleeding risk, which is increased by NSAIDs that also inhibit platelets and irritate the gastric mucosa. This raises the chance of significant gastrointestinal or other hemorrhage.
How serious is the interaction between Ibrutinib and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible, choose paracetamol for analgesia, and monitor for bleeding signs if combined. Consider gastroprotection.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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