Drug interactions
Ibrutinib + Lapatinib
Severity: Moderate
Ibrutinib and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4, the main enzyme metabolizing ibrutinib, which raises ibrutinib exposure. This increases the risk of bleeding, arrhythmia and other ibrutinib toxicities.
What this interaction means in plain words
Ibrutinib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibrutinib belongs to Oncology; Lapatinib belongs to Oncology.
Why it happens
Lapatinib inhibition of CYP3A4 reduces ibrutinib clearance.
What to do
Reduce ibrutinib dose as per labeling for moderate CYP3A4 inhibitors and monitor for toxicity. Restore the previous dose after lapatinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Lapatinib?
MediHelp rates the interaction as moderate. Ibrutinib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4, the main enzyme metabolizing ibrutinib, which raises ibrutinib exposure. This increases the risk of bleeding, arrhythmia and other ibrutinib toxicities.
How serious is the interaction between Ibrutinib and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce ibrutinib dose as per labeling for moderate CYP3A4 inhibitors and monitor for toxicity. Restore the previous dose after lapatinib is stopped.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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