Drug interactions
Ibrutinib + Nicardipine
Severity: Moderate
Ibrutinib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may raise ibrutinib exposure through CYP3A4 inhibition, increasing the risk of bleeding, arrhythmias, and cytopenias. The effect is smaller than with strong inhibitors.
What this interaction means in plain words
Ibrutinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibrutinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 reduces ibrutinib's extensive first-pass and systemic metabolism.
What to do
Monitor for ibrutinib toxicity including bleeding, atrial fibrillation, and hypertension. Reduce the ibrutinib dose per labeling for moderate CYP3A4 inhibitors if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Nicardipine?
MediHelp rates the interaction as moderate. Ibrutinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may raise ibrutinib exposure through CYP3A4 inhibition, increasing the risk of bleeding, arrhythmias, and cytopenias. The effect is smaller than with strong inhibitors.
How serious is the interaction between Ibrutinib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ibrutinib toxicity including bleeding, atrial fibrillation, and hypertension. Reduce the ibrutinib dose per labeling for moderate CYP3A4 inhibitors if adverse effects occur.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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