Drug interactions
Ibrutinib + Pneumococcal vaccine 13-valent
Severity: Moderate
Ibrutinib and Pneumococcal vaccine 13-valent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib dampens B-cell function and can reduce antibody responses to conjugate pneumococcal vaccine. Patients may be left with inadequate protection against pneumococcal infection, to which they are already prone.
What this interaction means in plain words
Ibrutinib and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibrutinib belongs to Oncology; Pneumococcal vaccine 13-valent belongs to Miscellaneous.
Why it happens
Ibrutinib inhibits Bruton tyrosine kinase, reducing B-cell activation and vaccine-specific antibody production.
What to do
Vaccinate before starting ibrutinib when possible; if given during therapy, consider measuring antibody response and revaccinating when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as moderate. Ibrutinib and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib dampens B-cell function and can reduce antibody responses to conjugate pneumococcal vaccine. Patients may be left with inadequate protection against pneumococcal infection, to which they are already prone.
How serious is the interaction between Ibrutinib and Pneumococcal vaccine 13-valent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting ibrutinib when possible; if given during therapy, consider measuring antibody response and revaccinating when feasible.
What other medicines interact with Pneumococcal vaccine 13-valent?
MediHelp also lists interactions of Pneumococcal vaccine 13-valent with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Pneumococcal vaccine 13-valent page.
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