Drug interactions
Ibrutinib + Quinidine
Severity: Moderate
Ibrutinib and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a weak to moderate CYP3A4 inhibitor and may raise ibrutinib exposure, increasing the risk of bleeding, atrial fibrillation and other adverse effects. The effect is smaller than with strong inhibitors.
What this interaction means in plain words
Ibrutinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibrutinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Inhibition of CYP3A4 (and possibly P-glycoprotein) reduces the first-pass and systemic metabolism of ibrutinib.
What to do
Monitor for bleeding, arrhythmia and ibrutinib toxicity, and reduce the ibrutinib dose per labeling if toxicity occurs. Consider an alternative antiarrhythmic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Quinidine?
MediHelp rates the interaction as moderate. Ibrutinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine is a weak to moderate CYP3A4 inhibitor and may raise ibrutinib exposure, increasing the risk of bleeding, atrial fibrillation and other adverse effects. The effect is smaller than with strong inhibitors.
How serious is the interaction between Ibrutinib and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding, arrhythmia and ibrutinib toxicity, and reduce the ibrutinib dose per labeling if toxicity occurs. Consider an alternative antiarrhythmic if feasible.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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