Drug interactions
Ibrutinib + Sertraline
Severity: Moderate
Ibrutinib and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib is metabolized mainly by CYP3A4, and sertraline is only a weak inhibitor, so any increase in ibrutinib exposure is likely small. Both drugs can impair platelet function, so bleeding risk may be increased.
What this interaction means in plain words
Ibrutinib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibrutinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Additive effects on bleeding via SSRI-related platelet serotonin depletion and BTK inhibition, with minor CYP3A4 inhibition.
What to do
No ibrutinib dose reduction is generally required for sertraline. Monitor for bruising and bleeding, especially if anticoagulants or antiplatelets are also used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Sertraline?
MediHelp rates the interaction as moderate. Ibrutinib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib is metabolized mainly by CYP3A4, and sertraline is only a weak inhibitor, so any increase in ibrutinib exposure is likely small. Both drugs can impair platelet function, so bleeding risk may be increased.
How serious is the interaction between Ibrutinib and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No ibrutinib dose reduction is generally required for sertraline. Monitor for bruising and bleeding, especially if anticoagulants or antiplatelets are also used.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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