Drug interactions
Ibuprofen + Lesinurad
Severity: Minor
Ibuprofen and Lesinurad: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lesinurad is metabolized mainly by CYP2C9, and ibuprofen is a CYP2C9 substrate that could compete with it. Any change in lesinurad exposure is likely small. Both drugs can also affect renal function.
What this interaction means in plain words
Ibuprofen and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Lesinurad belongs to Genitourinary.
Why it happens
Theoretical competition for CYP2C9 metabolism; clinical effect is not established.
What to do
No dose change is required. Monitor renal function, since lesinurad carries a renal adverse event warning and NSAIDs can also reduce renal perfusion.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Frequently asked questions
Can I take Ibuprofen with Lesinurad?
MediHelp rates the interaction as minor. Ibuprofen and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lesinurad is metabolized mainly by CYP2C9, and ibuprofen is a CYP2C9 substrate that could compete with it. Any change in lesinurad exposure is likely small. Both drugs can also affect renal function.
How serious is the interaction between Ibuprofen and Lesinurad?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required. Monitor renal function, since lesinurad carries a renal adverse event warning and NSAIDs can also reduce renal perfusion.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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