Drug interactions
Ibuprofen + Mesalamine
Severity: Moderate
Ibuprofen and Mesalamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mesalamine can cause interstitial nephritis, and NSAIDs reduce renal prostaglandin-mediated perfusion. Together they may raise the risk of kidney injury.
What this interaction means in plain words
Ibuprofen and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
Additive nephrotoxicity from mesalamine interstitial nephritis and NSAID-induced renal hemodynamic effects.
What to do
Monitor serum creatinine at baseline and periodically; avoid NSAIDs where possible in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mesalamine
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Mesalamine?
MediHelp rates the interaction as moderate. Ibuprofen and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mesalamine can cause interstitial nephritis, and NSAIDs reduce renal prostaglandin-mediated perfusion. Together they may raise the risk of kidney injury.
How serious is the interaction between Ibuprofen and Mesalamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine at baseline and periodically; avoid NSAIDs where possible in patients with renal impairment.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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