Drug interactions
Ibuprofen + Milnacipran
Severity: Moderate
Ibuprofen and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Milnacipran, an SNRI, impairs platelet serotonin uptake and ibuprofen inhibits platelet function and damages gastric mucosa. Together they raise the risk of bleeding, particularly from the upper gastrointestinal tract.
What this interaction means in plain words
Ibuprofen and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Milnacipran belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on platelet aggregation, combined with NSAID-induced gastric mucosal injury.
What to do
Watch for signs of GI bleeding such as melena, and use the lowest effective NSAID dose for the shortest time. Consider adding gastroprotection in older patients or those with prior ulcers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Ibuprofen with Milnacipran?
MediHelp rates the interaction as moderate. Ibuprofen and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Milnacipran, an SNRI, impairs platelet serotonin uptake and ibuprofen inhibits platelet function and damages gastric mucosa. Together they raise the risk of bleeding, particularly from the upper gastrointestinal tract.
How serious is the interaction between Ibuprofen and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of GI bleeding such as melena, and use the lowest effective NSAID dose for the shortest time. Consider adding gastroprotection in older patients or those with prior ulcers.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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