Drug interactions
Ibuprofen + Nebivolol
Severity: Moderate
Ibuprofen and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sustained NSAID use can reduce the antihypertensive effect of nebivolol. The effect is variable but may lead to loss of blood pressure control.
What this interaction means in plain words
Ibuprofen and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Nebivolol belongs to Cardiovascular.
Why it happens
NSAIDs inhibit vasodilatory prostaglandins and promote sodium and water retention, opposing the blood pressure lowering effect.
What to do
Monitor blood pressure if ibuprofen is used regularly and adjust therapy as needed. Consider paracetamol as an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Ibuprofen with Nebivolol?
MediHelp rates the interaction as moderate. Ibuprofen and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sustained NSAID use can reduce the antihypertensive effect of nebivolol. The effect is variable but may lead to loss of blood pressure control.
How serious is the interaction between Ibuprofen and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if ibuprofen is used regularly and adjust therapy as needed. Consider paracetamol as an alternative analgesic.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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