Drug interactions
Ibuprofen + Pexidartinib
Severity: Moderate
Ibuprofen and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and other drugs with hepatotoxic potential may add to the risk. Ibuprofen is only rarely hepatotoxic, but the combination warrants liver monitoring.
What this interaction means in plain words
Ibuprofen and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Pexidartinib belongs to Oncology.
Why it happens
Additive hepatotoxic potential; ibuprofen's idiosyncratic liver injury may compound pexidartinib hepatotoxicity.
What to do
Monitor liver tests per the pexidartinib program and prefer short, low-dose ibuprofen or an alternative analgesic. Stop the offending drugs if liver enzymes rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Ibuprofen with Pexidartinib?
MediHelp rates the interaction as moderate. Ibuprofen and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and other drugs with hepatotoxic potential may add to the risk. Ibuprofen is only rarely hepatotoxic, but the combination warrants liver monitoring.
How serious is the interaction between Ibuprofen and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver tests per the pexidartinib program and prefer short, low-dose ibuprofen or an alternative analgesic. Stop the offending drugs if liver enzymes rise significantly.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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