Drug interactions
Ibuprofen + Piperacillin
Severity: Minor
Ibuprofen and Piperacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are organic acids secreted by renal tubular transporters, so piperacillin could reduce ibuprofen clearance and modestly increase its exposure. NSAIDs may also impair renal function and reduce penicillin clearance. Clinical effect is usually small.
What this interaction means in plain words
Ibuprofen and Piperacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Piperacillin belongs to Anti Bacterial.
Why it happens
Competition for renal tubular anionic transport (OAT) secretion.
What to do
No routine adjustment; monitor renal function and for NSAID adverse effects in patients with renal impairment or high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piperacillin
- Piperacillin + Vancomycin Major
- Acetylsalicylic acid + Piperacillin Moderate
- Amikacin + Piperacillin Moderate
- Antithrombin alfa + Piperacillin Moderate
- Antithrombin iii + Piperacillin Moderate
- Argatroban + Piperacillin Moderate
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Piperacillin?
MediHelp rates the interaction as minor. Ibuprofen and Piperacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are organic acids secreted by renal tubular transporters, so piperacillin could reduce ibuprofen clearance and modestly increase its exposure. NSAIDs may also impair renal function and reduce penicillin clearance. Clinical effect is usually small.
How serious is the interaction between Ibuprofen and Piperacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor renal function and for NSAID adverse effects in patients with renal impairment or high doses.
What other medicines interact with Piperacillin?
MediHelp also lists interactions of Piperacillin with, for example, Vancomycin, Acetylsalicylic acid, Amikacin. The full list is on the Piperacillin page.
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