Drug interactions
Ibuprofen + Pralatrexate
Severity: Moderate
Ibuprofen and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the renal clearance of pralatrexate, raising exposure and the risk of mucositis, myelosuppression and other toxicity.
What this interaction means in plain words
Ibuprofen and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Pralatrexate belongs to Oncology.
Why it happens
Competition for renal tubular secretion and NSAID-related reduction in renal blood flow delay pralatrexate elimination.
What to do
Monitor for mucositis and cytopenias, and renal function. Consider holding the NSAID or adjusting the pralatrexate dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Pralatrexate
Frequently asked questions
Can I take Ibuprofen with Pralatrexate?
MediHelp rates the interaction as moderate. Ibuprofen and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the renal clearance of pralatrexate, raising exposure and the risk of mucositis, myelosuppression and other toxicity.
How serious is the interaction between Ibuprofen and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mucositis and cytopenias, and renal function. Consider holding the NSAID or adjusting the pralatrexate dose if toxicity develops.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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