Drug interactions
Ibuprofen + Probenecid
Severity: Moderate
Ibuprofen and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces renal clearance of NSAIDs, which may increase ibuprofen exposure and adverse effects. Ibuprofen's competition with probenecid may also slightly blunt uricosuric activity.
What this interaction means in plain words
Ibuprofen and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits organic anion transporters in the renal tubule, decreasing ibuprofen secretion.
What to do
Monitor for NSAID adverse effects such as GI upset or renal changes, and use a lower ibuprofen dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Ibuprofen with Probenecid?
MediHelp rates the interaction as moderate. Ibuprofen and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces renal clearance of NSAIDs, which may increase ibuprofen exposure and adverse effects. Ibuprofen's competition with probenecid may also slightly blunt uricosuric activity.
How serious is the interaction between Ibuprofen and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID adverse effects such as GI upset or renal changes, and use a lower ibuprofen dose if needed.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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