Drug interactions
Ibuprofen + Tolazamide
Severity: Moderate
Ibuprofen and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen may enhance the glucose-lowering effect of sulfonylureas such as tolazamide, raising the risk of hypoglycemia. The effect is usually modest but can matter in older patients or those with renal impairment.
What this interaction means in plain words
Ibuprofen and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Tolazamide belongs to Endocrine.
Why it happens
Possible displacement of the sulfonylurea from plasma protein binding and reduced renal clearance; the mechanism is not fully established.
What to do
Monitor blood glucose when starting or stopping ibuprofen and counsel the patient on hypoglycemia symptoms. Reduce the tolazamide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Ibuprofen with Tolazamide?
MediHelp rates the interaction as moderate. Ibuprofen and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen may enhance the glucose-lowering effect of sulfonylureas such as tolazamide, raising the risk of hypoglycemia. The effect is usually modest but can matter in older patients or those with renal impairment.
How serious is the interaction between Ibuprofen and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping ibuprofen and counsel the patient on hypoglycemia symptoms. Reduce the tolazamide dose if glucose falls.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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