Drug interactions
Ibuprofen + Voclosporin
Severity: Major
Ibuprofen and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can reduce glomerular filtration through afferent arteriolar vasoconstriction. NSAIDs further reduce renal prostaglandin-dependent perfusion, so combined use raises the risk of acute kidney injury.
What this interaction means in plain words
Ibuprofen and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ibuprofen belongs to Musculoskeletal; Voclosporin belongs to Miscellaneous.
Why it happens
Additive renal hemodynamic effects: calcineurin inhibitor afferent vasoconstriction plus NSAID inhibition of vasodilatory prostaglandins.
What to do
Avoid regular NSAID use in patients taking voclosporin and use alternative analgesia such as paracetamol. If unavoidable, monitor eGFR and serum creatinine closely and adjust voclosporin as per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Ibuprofen with Voclosporin?
MediHelp rates the interaction as major. Ibuprofen and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin is a calcineurin inhibitor that can reduce glomerular filtration through afferent arteriolar vasoconstriction. NSAIDs further reduce renal prostaglandin-dependent perfusion, so combined use raises the risk of acute kidney injury.
How serious is the interaction between Ibuprofen and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use in patients taking voclosporin and use alternative analgesia such as paracetamol. If unavoidable, monitor eGFR and serum creatinine closely and adjust voclosporin as per labeling.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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