Drug interactions
ibuprofen + warfarin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive bleeding risk (GI).
Mechanism of action
Platelet/COX effects + anticoagulation.
Clinical management
Avoid NSAIDs; prefer acetaminophen (≤2 g/day) and monitor.
Drug reference
References
Frequently asked questions
Can I take ibuprofen with warfarin?
The interaction is rated: Major. Additive bleeding risk (GI).
How serious is the interaction between ibuprofen and warfarin?
The interaction is rated: Major. Evidence level: High.
How is the interaction between ibuprofen and warfarin managed?
Avoid NSAIDs; prefer acetaminophen (≤2 g/day) and monitor.
Why do ibuprofen and warfarin interact?
Platelet/COX effects + anticoagulation.
Full monographs, dosing and an interaction checker in the MediHelp app
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