Drug interactions
Ibuprofen + Zafirlukast
Severity: Minor
Ibuprofen and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen is cleared mainly by CYP2C9, which zafirlukast can inhibit in vitro. Any rise in ibuprofen exposure is expected to be small and of little clinical consequence.
What this interaction means in plain words
Ibuprofen and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Zafirlukast belongs to Respiratory.
Why it happens
Zafirlukast may inhibit CYP2C9-mediated metabolism of ibuprofen.
What to do
No routine action is needed. Use the lowest effective ibuprofen dose and monitor for GI upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Zafirlukast?
MediHelp rates the interaction as minor. Ibuprofen and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ibuprofen is cleared mainly by CYP2C9, which zafirlukast can inhibit in vitro. Any rise in ibuprofen exposure is expected to be small and of little clinical consequence.
How serious is the interaction between Ibuprofen and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Use the lowest effective ibuprofen dose and monitor for GI upset.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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