Drug interactions
Ibuprofen / famotidine + Itraconazole
Severity: Moderate
Ibuprofen / famotidine and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine raises gastric pH, which markedly reduces absorption of itraconazole capsules and may lead to subtherapeutic antifungal levels and treatment failure. Ibuprofen itself does not contribute to this effect.
What this interaction means in plain words
Ibuprofen / famotidine and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Famotidine, an H2 blocker, increases gastric pH, which reduces dissolution and absorption of pH-dependent itraconazole capsules.
What to do
Use itraconazole oral solution or SUBA-itraconazole formulations, which are less dependent on acid, or take capsules with an acidic beverage. Monitor itraconazole levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Ibuprofen / famotidine with Itraconazole?
MediHelp rates the interaction as moderate. Ibuprofen / famotidine and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Famotidine raises gastric pH, which markedly reduces absorption of itraconazole capsules and may lead to subtherapeutic antifungal levels and treatment failure. Ibuprofen itself does not contribute to this effect.
How serious is the interaction between Ibuprofen / famotidine and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use itraconazole oral solution or SUBA-itraconazole formulations, which are less dependent on acid, or take capsules with an acidic beverage. Monitor itraconazole levels and clinical response.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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