Drug interactions
Ibuprofen / famotidine + Mefloquine
Severity: Minor
Ibuprofen / famotidine and Mefloquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen does not meaningfully prolong QT, and famotidine has only a minor, mostly renal-impairment-related QT signal. A clinically important interaction with mefloquine is not well established.
What this interaction means in plain words
Ibuprofen / famotidine and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; any additive QT effect is theoretical.
What to do
No routine action is required. Check the ECG only if there is renal impairment or other QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ibuprofen / famotidine and Mefloquine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Ibuprofen / famotidine with Mefloquine?
MediHelp rates the interaction as minor. Ibuprofen / famotidine and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ibuprofen does not meaningfully prolong QT, and famotidine has only a minor, mostly renal-impairment-related QT signal. A clinically important interaction with mefloquine is not well established.
How serious is the interaction between Ibuprofen / famotidine and Mefloquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required. Check the ECG only if there is renal impairment or other QT risk factors.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
