Drug interactions
Icosapent + Mefenamic acid
Severity: Moderate
Icosapent and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icosapent ethyl can prolong bleeding time modestly, and NSAIDs add antiplatelet and gastrointestinal bleeding risk. The combination may increase bleeding, although clinically significant events are infrequent.
What this interaction means in plain words
Icosapent and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects of EPA and NSAID-mediated COX-1 inhibition.
What to do
Monitor for signs of bleeding, especially in patients also taking anticoagulants or with GI risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Icosapent with Mefenamic acid?
MediHelp rates the interaction as moderate. Icosapent and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Icosapent ethyl can prolong bleeding time modestly, and NSAIDs add antiplatelet and gastrointestinal bleeding risk. The combination may increase bleeding, although clinically significant events are infrequent.
How serious is the interaction between Icosapent and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding, especially in patients also taking anticoagulants or with GI risk factors.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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