Drug interactions
Icosapent + Piroxicam
Severity: Minor
Icosapent and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icosapent ethyl may modestly prolong bleeding time, which can add to the bleeding risk of piroxicam. Clinically important bleeding is uncommon.
What this interaction means in plain words
Icosapent and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Omega-3 reduction of platelet aggregation is additive with NSAID platelet inhibition.
What to do
Monitor for bleeding periodically, especially in patients also taking anticoagulants or with a history of GI bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Icosapent with Piroxicam?
MediHelp rates the interaction as minor. Icosapent and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icosapent ethyl may modestly prolong bleeding time, which can add to the bleeding risk of piroxicam. Clinically important bleeding is uncommon.
How serious is the interaction between Icosapent and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding periodically, especially in patients also taking anticoagulants or with a history of GI bleeding.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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