Drug interactions
Icosapent + Rivaroxaban
Severity: Minor
Icosapent and Rivaroxaban: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icosapent ethyl may prolong bleeding time, and combined with rivaroxaban it can slightly increase bleeding risk. Clinical bleeding events have been mostly minor.
What this interaction means in plain words
Icosapent and Rivaroxaban have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic effect through mild antiplatelet action of EPA.
What to do
No dose adjustment is usually needed, but monitor for bleeding periodically. Counsel patients to report unusual bruising or bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Icosapent with Rivaroxaban?
MediHelp rates the interaction as minor. Icosapent and Rivaroxaban have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icosapent ethyl may prolong bleeding time, and combined with rivaroxaban it can slightly increase bleeding risk. Clinical bleeding events have been mostly minor.
How serious is the interaction between Icosapent and Rivaroxaban?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed, but monitor for bleeding periodically. Counsel patients to report unusual bruising or bleeding.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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