Drug interactions
Idarubicin + Lomitapide
Severity: Moderate
Idarubicin and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein and could raise idarubicin exposure. Both agents can cause hepatotoxicity, so overlapping liver injury is also a concern.
What this interaction means in plain words
Idarubicin and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idarubicin belongs to Oncology; Lomitapide belongs to Cardiovascular.
Why it happens
Lomitapide inhibits P-glycoprotein, reducing idarubicin efflux.
What to do
Monitor liver enzymes, blood counts and cardiac status. Consider reducing the idarubicin dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idarubicin
- Adenovirus types 4 and 7 live + Idarubicin Contraindicated
- Belatacept + Idarubicin Major
- Cyclophosphamide + Idarubicin Major
- Deferiprone + Idarubicin Major
- Dengue vaccine + Idarubicin Major
- Etrasimod + Idarubicin Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Idarubicin with Lomitapide?
MediHelp rates the interaction as moderate. Idarubicin and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide inhibits P-glycoprotein and could raise idarubicin exposure. Both agents can cause hepatotoxicity, so overlapping liver injury is also a concern.
How serious is the interaction between Idarubicin and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, blood counts and cardiac status. Consider reducing the idarubicin dose if toxicity occurs.
What other medicines interact with Idarubicin?
MediHelp also lists interactions of Idarubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclophosphamide. The full list is on the Idarubicin page.
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