Drug interactions
Idarubicin + Lonafarnib
Severity: Minor
Idarubicin and Lonafarnib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a weak P-glycoprotein inhibitor and may slightly increase idarubicin exposure. The clinical effect is probably small but idarubicin has a narrow therapeutic margin.
What this interaction means in plain words
Idarubicin and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Idarubicin belongs to Oncology; Lonafarnib belongs to Miscellaneous.
Why it happens
Lonafarnib weakly inhibits P-glycoprotein efflux of idarubicin.
What to do
Monitor blood counts and for signs of anthracycline toxicity. Reduce the idarubicin dose if adverse effects develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Idarubicin
- Adenovirus types 4 and 7 live + Idarubicin Contraindicated
- Belatacept + Idarubicin Major
- Cyclophosphamide + Idarubicin Major
- Deferiprone + Idarubicin Major
- Dengue vaccine + Idarubicin Major
- Etrasimod + Idarubicin Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Idarubicin with Lonafarnib?
MediHelp rates the interaction as minor. Idarubicin and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a weak P-glycoprotein inhibitor and may slightly increase idarubicin exposure. The clinical effect is probably small but idarubicin has a narrow therapeutic margin.
How serious is the interaction between Idarubicin and Lonafarnib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of anthracycline toxicity. Reduce the idarubicin dose if adverse effects develop.
What other medicines interact with Idarubicin?
MediHelp also lists interactions of Idarubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclophosphamide. The full list is on the Idarubicin page.
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