Drug interactions
Ifosfamide + Isavuconazonium
Severity: Moderate
Ifosfamide and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor and may change ifosfamide activation and toxic metabolite formation. Both agents may also add to infection risk in an immunocompromised patient, although isavuconazonium is an antifungal rather than an immunosuppressant.
What this interaction means in plain words
Ifosfamide and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Isavuconazonium belongs to Anti Fungals.
Why it happens
Moderate CYP3A4 inhibition by isavuconazole alters ifosfamide metabolism.
What to do
Monitor for ifosfamide neurotoxicity, nephrotoxicity and treatment response while the antifungal is co-administered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Ifosfamide with Isavuconazonium?
MediHelp rates the interaction as moderate. Ifosfamide and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a moderate CYP3A4 inhibitor and may change ifosfamide activation and toxic metabolite formation. Both agents may also add to infection risk in an immunocompromised patient, although isavuconazonium is an antifungal rather than an immunosuppressant.
How serious is the interaction between Ifosfamide and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ifosfamide neurotoxicity, nephrotoxicity and treatment response while the antifungal is co-administered.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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