Drug interactions
Ifosfamide + Natalizumab
Severity: Major
Ifosfamide and Natalizumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide is a myelosuppressive alkylating chemotherapy agent. Together with natalizumab, immunosuppression increases, with a higher risk of serious and opportunistic infections including PML.
What this interaction means in plain words
Ifosfamide and Natalizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ifosfamide belongs to Oncology; Natalizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from cytotoxic myelosuppression and blockade of lymphocyte trafficking.
What to do
Avoid concurrent use where possible. If necessary, monitor blood counts and watch for infection and neurological changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Natalizumab
- Natalizumab + Vedolizumab Contraindicated
- Axicabtagene ciloleucel + Natalizumab Major
- Baricitinib + Natalizumab Major
- Belatacept + Natalizumab Major
- Brexucabtagene autoleucel + Natalizumab Major
- Cabazitaxel + Natalizumab Major
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Natalizumab?
MediHelp rates the interaction as major. Ifosfamide and Natalizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ifosfamide is a myelosuppressive alkylating chemotherapy agent. Together with natalizumab, immunosuppression increases, with a higher risk of serious and opportunistic infections including PML.
How serious is the interaction between Ifosfamide and Natalizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If necessary, monitor blood counts and watch for infection and neurological changes.
What other medicines interact with Natalizumab?
MediHelp also lists interactions of Natalizumab with, for example, Vedolizumab, Axicabtagene ciloleucel, Baricitinib. The full list is on the Natalizumab page.
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