Drug interactions
Ifosfamide + Paclitaxel
Severity: Moderate
Ifosfamide and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two drugs are often combined and share myelosuppression and neurotoxicity, which may be additive. The suggested CYP2C8-based increase in paclitaxel exposure is not well established.
What this interaction means in plain words
Ifosfamide and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
Additive myelosuppression and neurotoxicity; a pharmacokinetic effect on paclitaxel is not firmly established.
What to do
Monitor blood counts and peripheral and central neurotoxicity, and reduce doses if severe toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Paclitaxel
Frequently asked questions
Can I take Ifosfamide with Paclitaxel?
MediHelp rates the interaction as moderate. Ifosfamide and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The two drugs are often combined and share myelosuppression and neurotoxicity, which may be additive. The suggested CYP2C8-based increase in paclitaxel exposure is not well established.
How serious is the interaction between Ifosfamide and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and peripheral and central neurotoxicity, and reduce doses if severe toxicity occurs.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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