Drug interactions
Ifosfamide + Prednisone
Severity: Moderate
Ifosfamide and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids are commonly used with ifosfamide in chemotherapy regimens, but combined immunosuppression raises the risk of infection. Prednisone may also slightly alter ifosfamide activation, though this is of uncertain relevance.
What this interaction means in plain words
Ifosfamide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Prednisone belongs to Endocrine.
Why it happens
Additive immunosuppression and myelosuppression, with possible minor effects on CYP-mediated ifosfamide activation.
What to do
Monitor blood counts and for signs of infection, and consider antimicrobial prophylaxis according to the regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Prednisone?
MediHelp rates the interaction as moderate. Ifosfamide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids are commonly used with ifosfamide in chemotherapy regimens, but combined immunosuppression raises the risk of infection. Prednisone may also slightly alter ifosfamide activation, though this is of uncertain relevance.
How serious is the interaction between Ifosfamide and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of infection, and consider antimicrobial prophylaxis according to the regimen.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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