Drug interactions
Ifosfamide + Primaquine
Severity: Moderate
Ifosfamide and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can suppress bone marrow or damage blood cells, so using them together may increase the risk of anemia and other cytopenias. Primaquine can also cause hemolysis, especially in G6PD deficiency, which could add to chemotherapy-related anemia.
What this interaction means in plain words
Ifosfamide and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Primaquine belongs to Anti Parasitic.
Why it happens
Additive hematologic toxicity: myelosuppression from ifosfamide and oxidative hemolysis from primaquine.
What to do
Check G6PD status before primaquine and monitor complete blood counts regularly during co-therapy. Delay or adjust primaquine if significant hemolysis or cytopenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Primaquine?
MediHelp rates the interaction as moderate. Ifosfamide and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can suppress bone marrow or damage blood cells, so using them together may increase the risk of anemia and other cytopenias. Primaquine can also cause hemolysis, especially in G6PD deficiency, which could add to chemotherapy-related anemia.
How serious is the interaction between Ifosfamide and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check G6PD status before primaquine and monitor complete blood counts regularly during co-therapy. Delay or adjust primaquine if significant hemolysis or cytopenia develops.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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