Drug interactions
Ifosfamide + Rifapentine
Severity: Moderate
Ifosfamide and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is a CYP3A4 inducer that can increase conversion of ifosfamide to alkylating metabolites and to chloroacetaldehyde. This may raise the risk of neurotoxicity, nephrotoxicity and myelosuppression.
What this interaction means in plain words
Ifosfamide and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Rifapentine belongs to Anti Bacterial.
Why it happens
CYP3A4 (and likely CYP2B6) induction increases ifosfamide metabolism.
What to do
Consider alternative antimycobacterial therapy when feasible. If combined, monitor renal function, mental status and blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Ifosfamide with Rifapentine?
MediHelp rates the interaction as moderate. Ifosfamide and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine is a CYP3A4 inducer that can increase conversion of ifosfamide to alkylating metabolites and to chloroacetaldehyde. This may raise the risk of neurotoxicity, nephrotoxicity and myelosuppression.
How serious is the interaction between Ifosfamide and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider alternative antimycobacterial therapy when feasible. If combined, monitor renal function, mental status and blood counts.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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