Drug interactions
Ifosfamide + Secobarbital
Severity: Moderate
Ifosfamide and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may induce enzymes that convert ifosfamide to its active metabolites, raising active metabolite formation. This can increase toxicity, including neurotoxicity and myelosuppression, and also shift production toward neurotoxic chloroacetaldehyde.
What this interaction means in plain words
Ifosfamide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of CYP2B6 and CYP3A4 by secobarbital increases ifosfamide bioactivation and metabolite formation.
What to do
Avoid enzyme-inducing barbiturates if possible. If they are used, monitor closely for CNS toxicity, myelosuppression and urotoxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Secobarbital?
MediHelp rates the interaction as moderate. Ifosfamide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may induce enzymes that convert ifosfamide to its active metabolites, raising active metabolite formation. This can increase toxicity, including neurotoxicity and myelosuppression, and also shift production toward neurotoxic chloroacetaldehyde.
How serious is the interaction between Ifosfamide and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid enzyme-inducing barbiturates if possible. If they are used, monitor closely for CNS toxicity, myelosuppression and urotoxicity.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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