Drug interactions
Ifosfamide + Sparsentan
Severity: Minor
Ifosfamide and Sparsentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is a weak CYP3A4 inducer, but CYP2C19 is only a minor route of ifosfamide metabolism. A clinically important change in ifosfamide exposure is not well documented. Possible CYP3A4 induction could modestly shift ifosfamide metabolism.
What this interaction means in plain words
Ifosfamide and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ifosfamide belongs to Oncology; Sparsentan belongs to Genitourinary.
Why it happens
Weak enzyme induction by sparsentan may slightly alter ifosfamide metabolism; clinical significance is not established.
What to do
No routine adjustment is needed. Monitor for changes in ifosfamide response or toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Ifosfamide with Sparsentan?
MediHelp rates the interaction as minor. Ifosfamide and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sparsentan is a weak CYP3A4 inducer, but CYP2C19 is only a minor route of ifosfamide metabolism. A clinically important change in ifosfamide exposure is not well documented. Possible CYP3A4 induction could modestly shift ifosfamide metabolism.
How serious is the interaction between Ifosfamide and Sparsentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for changes in ifosfamide response or toxicity.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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